Imaging under liquids using dynamic AFM techniques is often difficult because of the greatly reduced quality factor (Q-factor) of the cantilever resonance. Even so, Nanotec New Lanza AFM Head have been tested using Frequency Modulation, allowing True Atomic Resolution in liquids to be achieved.
Furthermore, Nanotec has developed a new technique called Jumping Mode plus(JM+) which is now implemented in Nanotec’s Cervantes Full-Mode AFM. Using JM+, the user has unprecedented control of relevant imaging parameters, performing high-resolution AFM measurements of biological samples in their proper environment.
- Bioinspired Fibers Follow the Track of Natural Spider Silk
M. Elices, G. V. Guinea, G. R. Plaza, C. Karatzas, C. Riekel, F. Agullo-Rueda, R. Daza, and J. Perez-Rigueiro, 2011, 44 (5), pp 1166-1176 DOI: 10.1021/ma102291m Macromolecules
- Squeezing protein shells: how continuum elastic models, molecular dynamics simulations and experiments coalesce at the nanoscale
W. H. Roos, M. M. Gibbons, A. Arkhipov, C. Uetrecht, N. Watts, P. Wingfield, A. C. Steven, A. Heck, K. Schulten, W. Klug, G. J. L. Wuite, Biophys. J., Vol. 99, 1175-1181 (2010) Biophysical Journal
- Scaffold expulsion and genome packaging trigger stabilization of Herpes Simplex Virus capsids
W. H. Roos, K. Radtke, E. Kniesmeijer, H. Geertsema, B. Sodeik, G. J. L. Wuite,
PNAS, Vol. 106, 9673-9678 (2009)
- The capillarity of nanometric water menisci confined inside closed-geometry viral cages
C. Carrasco, M. Douas, R. Miranda, M. Castellanos, P. A. Serena, J. L. Carrascos, M. G. Mateu, M. I. Marqués and P. J. de Pablo. PNAS, 106, No. 14, 5475–5480 (2009)
- Supramolecular organization of regenerated silkworm silk fibers
J. Pérez-Rigueiro et al. International Journal of Biological Macromolecules 44, 195–202 (2009)
- DNA molecules resolved by electrical double layer force spectroscopy
imaging
J. Sotres and A. M. Baró. Appl. Phys. Lett. 93 (2008)
- Manipulation of the mechanical properties of a virus by protein engineering
Carolina Carrasco, Milagros Castellanos, Pedro J. de Pablo, and Mauricio G. Mateu. PNAS, 105, no. 11, 4150–4155 (2008)
- In Vitro Reconstitution of the Initial Stages of the Bacterial Cell Division Machinery
Pilar López Navajas, Germán Rivas, Jesús Mingorance, Pablo Mateos-Gil, Ines Hörger, Enrique Velasco, Pedro Tarazona, Marisela Vélez. J Biol Phys 34, 237–247 (2008)
- Quasi-simultaneous imaging/pulling analysis of single polyprotein
molecules by atomic force microscopy
Alejandro Valbuena, Javier Oroz, and Andrés Manuel Vera, Alejandro Gimeno, Julio Gómez-Herrero, Mariano Carrión-Vázquez. Rev. Sci. Instrum. 78, (2007)
- Plasmas and atom beam activation of the
surface of polymers
C López-Santos, F Yubero, J Cotrino, A Barranco and A R González-Elipe J. Phys. D: Appl. Phys. 41 (2008) 225209
- Jumping mode AFM imaging of biomolecules in the repulsive electrical double layer
J. Sotres et al. Ultramicroscopy 107 , 1207-1212 (2007)
- Hydrogenase-Coated Carbon Nanotubes
for Efficient H2 Oxidation
M. Asunción Alonso-Lomillo, Olaf Rüdiger, Angel Maroto-Valiente,
Marisela Velez,| Inmaculada Rodríguez-Ramos, F. Javier Muñoz,
Víctor M. Fernández, and Antonio L. De Lacey. Nano Lett., Vol. 7, No. 6 (2007)
- Internal DNA pressure modifies stability of WT phage
Irena Ivanovska, Gijs Wuite, Bengt Jönsson, and Alex Evilevitch. PNAS 104, no. 23, 9603–9608 (2007).
- Elastic Response, Buckling, and Instability of Microtubules under Radial Indentation
Iwan A. T. Schaap et al. Biophysical Journal 91 , 1521–1531 (2006)
- DNA-mediated anisotropic mechanical reinforcement of a virus
Carrasco et al. PNAS 103, 13706-13711 (2006)
- Nanoindentation studies of full and empty viral
capsids and the effects of capsid protein mutations
on elasticity and strength
J. P. Michel, I. L. Ivanovska, M. M. Gibbons, W. S. Klug, C. M. Knobler, G. J. L. Wuite, and C. F. Schmidt, PNAS 103, no. 16, 6184–6189 (2006)
- Resolving the molecular structure of microtubules under physiological conditions with scanning force microscopy
de Pablo et al. Biophysics Letter 33 , 462-467 (2004)
- Bacteriophage capsids: Tough nanoshells with complex elastic properties
I.L.Ivanovska et al. PNAS 101 , 7600-7605 (2004)
- Jumping mode scanning force microscopy: a suitable technique for imaging DNA in liquids
Moreno-Herrero et al. Applied Surface Science 210 , 22-26 (2003)
- Observation of microtubules with scanning force microscopy in liquid
de Pablo et al. Nanotechnology 14 , 143-146 (2003)
